Early in life, development and experience interact to build a foundation for the lifespan, leaving an indelible impression on lifelong outcomes. Deepening scientific understanding of how early development and experience, from the prenatal period through age six, shape learning, well-being, health and disease is essential to the welfare of our society. Innovations in Developmental Sciences, (“DevSci”) is designed to transform how scientists ask and answer questions about how early development shapes the lifespan.